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T cells are the shock troops of the human immune system – they can be ordered to kill what they recognise. Remarkably nearly every T cell is uniquely different to each other due to mutations that occur during the synthesis of their T cell receptor (TCR).

It is the highly specific binding of a T cell receptor to a molecular shape expressed on the surface of other cells, that mediates their function. To study the development and specificity of an immune response to a new immune target we are endeavouring to determine the structure of the TCR's of the T cells involved.

This talk will describe the approach taken to select the reactive T cells from a donor's blood cells and then grow from them clones. In the process amplifying in culture a single T cell into a bulk population of millions, thus enabling subsequent sequence analysis and functional assays.

Thursday 24 November @ 4pm
CMCA Seminar Room
ALL WELCOME